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Cell Host Microbe. 2013 Apr 17;13(4):377-8. doi: 10.1016/j.chom.2013.04.001.

Taking sides: interferons in leprosy.

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  • 1New York University School of Medicine, 522 First Avenue, Smilow 901, New York, NY 10016, USA.

Abstract

In a recent Science paper, Teles et al. (2013) show that type I and II interferons (IFNs) are reciprocally expressed in the polar immune forms of leprosy, with type I IFNs inducing IL-10 that interferes with the antimycobacterial effects of type II IFNs (IFNγ) at the site of infection.

Copyright © 2013 Elsevier Inc. All rights reserved.

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PMID:
23601100
[PubMed]
PMCID:
PMC3671607
Free PMC Article

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