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Oncol Lett. 2013 Apr;5(4):1093-1100. Epub 2013 Jan 22.

Expression of the PXR gene in various types of cancer and drug resistance.

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  • 1Department of General Surgery, Jiangsu Cancer Hospital, Affiliated to Nanjing Medical University, Nanjing 210009;

Abstract

Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporters, suggesting that it is significant in the drug resistance of cancer cells. PXR is expressed in a wide range of tissues in the human body. Studies have demonstrated that PXR is expressed in a variety of tumor types, correlating not only with drug resistance but also with the cell proliferation, apoptosis and prognosis of cancer. The purpose of the present review is to provide a comprehensive review of PXR and its potential roles in multidrug resistance and the biological characteristics of PXR-positive tumors.

KEYWORDS:

cancer; multidrug resistance; pregnane X receptor; tumor cell apoptosis

PMID:
23599746
[PubMed]
PMCID:
PMC3628904
Free PMC Article
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