Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Indian J Radiol Imaging. 2012 Jul;22(3):178-81. doi: 10.4103/0971-3026.107178.

Atypical femoral fractures related to bisphosphonate therapy.

Author information

  • 1Queensland X ray, 76 Willetts Road, Mackay - 4740, Queensland, Australia.


Bisphosphonates (BP) are a commonly prescribed class of drugs for the prevention of osteoporosis-related fractures. Paradoxically, however, they have recently been linked to atypical fractures in the shaft of the femur. Since many physicians including radiologists, are not aware of this entity, the incidence is likely underreported. These fractures usually occur in the sub-trochanteric region of the femur in the setting of low-energy trauma. It starts as a fracture line involving the lateral cortex and then progresses medially to give rise to a complete fracture. The fracture line is usually transverse, and there is a medial spike associated with a complete fracture. These fractures can be bilateral. Awareness of these atypical fractures and their radiological appearance should enable their early and accurate detection and thus lead to specific treatment.


Bisphosphonates; femoral fractures; hip fractures

Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1 (A-C)
Figure 2 (A-C)
Figure 3 (A, B)
Figure 4 (A, B)
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk