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Head Neck. 2014 May;36(5):611-6. doi: 10.1002/hed.23342. Epub 2013 Jul 2.

Risk of fatal cerebrovascular accidents after external beam radiation therapy for early-stage glottic laryngeal cancer.

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  • 1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Abstract

BACKGROUND:

This study compared the risk of fatal cerebrovascular accidents (CVAs) in patients with early-stage glottic laryngeal cancer receiving surgery or external beam radiation therapy (EBRT).

METHODS:

Using a competing risks survival analysis, we compared the risk of death because of CVA among patients with early-stage glottic laryngeal cancer receiving surgery or EBRT in the Surveillance, Epidemiology, and End Results (SEER) database.

RESULTS:

The cumulative incidence of fatal CVA at 15 years was higher in patients receiving EBRT (2.8%; 95% confidence interval [CI], 2.3% to 3.4%) compared to surgery (1.5%; 95% CI, 0.8% to 2.3%; p = .024). In multivariable competing risks regression models, EBRT remained associated with an increased risk of fatal CVA compared to surgery (adjusted hazard ratio [HR], 1.75; 95% CI, 1.04-2.96; p = .037).

CONCLUSION:

Treatment for early-stage glottic laryngeal cancer with EBRT was associated with a small increase in the risk of late fatal CVA events relative to surgery.

Copyright © 2013 Wiley Periodicals, Inc.

KEYWORDS:

cerebrovascular accidents; laryngeal cancer; radiation therapy

PMID:
23595858
[PubMed - indexed for MEDLINE]
PMCID:
PMC3795979
Free PMC Article
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