Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cough. 2013 Apr 16;9(1):12. doi: 10.1186/1745-9974-9-12.

The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes.

Author information

  • 1Respiratory and Allergy Centre, The University of Manchester, University Hospital of South Manchester, Manchester, UK. jacky.smith@manchester.ac.uk.

Abstract

Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed.

PMID:
23590893
[PubMed]
PMCID:
PMC3640905
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk