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FEBS Lett. 2013 May 21;587(10):1460-5. doi: 10.1016/j.febslet.2013.03.033. Epub 2013 Apr 10.

Two leucines in the N-terminal MAPK-docking site of tomato SlMKK2 are critical for interaction with a downstream MAPK to elicit programmed cell death associated with plant immunity.

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  • 1Department of Horticultural Biotechnology, Kyung Hee University, Yongin 446-701, Republic of Korea. co35@khu.ac.kr

Abstract

Tomato MAPK kinase SlMKK2 is a key protein regulating immunity-associated programmed cell death (PCD) in plants. We examined the role of the N-terminal MAPK-docking site (or D-site) of SlMKK2 in PCD elicitation. In vivo assays revealed that SlMKK2 interacted with the downstream MAPK SlMPK3 independent of PCD elicitation and two conserved leucines in the D-site were required for both interaction with SlMPK3 and PCD elicitation. These results demonstrate that two leucines in the D-site of SlMKK2 play a critical role in regulation of signal transfer to the downstream MAPK by regulating their physical interaction.

Copyright © 2013 Federation of European Biochemical Societies. All rights reserved.

PMID:
23583714
[PubMed - indexed for MEDLINE]
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