Send to

Choose Destination
See comment in PubMed Commons below
Health Phys. 1990 Jul;59(1):99-102.

Risk estimates: past, present, and future.

Author information

  • 1Radiation Effects Research Foundation, Hiroshima, Japan.


Risk estimates for genetic disease developed over the past 30 y have been reviewed. The influence of dose rate and nonlinear dose-response curves on low dose estimates are discussed, and a reevaluation of doubling dose from acute irradiation is presented. The issue of differential sensitivity between human and mouse data are discussed with respect to the lack of an observable induced mutation rate in the offspring of A-bomb survivors. It is concluded that the "presumably" more sensitive mouse-derived risk estimates would not predict a significant increase in F1 abnormalities in humans. Therefore, it may be premature to accept the interpretation that man is less radiosensitive than the mouse.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk