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Biochem Biophys Res Commun. 2013 May 10;434(3):653-8. doi: 10.1016/j.bbrc.2013.03.137. Epub 2013 Apr 11.

Glycogen synthase kinase 3 alpha phosphorylates and regulates the osteogenic activity of Osterix.

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  • 1College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea.

Abstract

Osteoblast-specific transcription factor Osterix is a zinc-finger transcription factor that required for osteoblast differentiation and new bone formation. The function of Osterix can be modulated by post-translational modification. Glycogen synthase kinase 3 alpha (GSK3α) is a multifunctional serine/threonine protein kinase that plays a role in the Wnt signaling pathways and is implicated in the control of several regulatory proteins and transcription factors. In the present study, we investigated how GSK3α regulates Osterix during osteoblast differentiation. Wide type GSK3α up-regulated the protein level, protein stability and transcriptional activity of Osterix. These results suggest that GSK3α regulates osteogenic activity of Osterix.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23583239
[PubMed - indexed for MEDLINE]
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