Hum Genet. 1990 Jun;85(1):98-100.

Identification of a hypervariable microsatellite polymorphism within D9S15 tightly linked to Friedrich's ataxia.

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Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, UK.

Abstract

We have identified a hypervariable microsatellite sequence within the chromosome 9 marker MCT112 (D9S15), which we have previously shown to be tightly linked to Friedreich's ataxia (FRDA). The system detects 7 alleles ranging in size from 195 to 209 base pairs, and substantially increases informativity at the MCT112 locus. This enhances its use for genetic counselling in affected families. Recalculated combined linkage data between the FRDA locus and MCT112 gives a maximal lod score of 66.91 at a recombination fraction of theta = 0). There is no evidence of linkage disequilibrium.

PMID:: 2358306; [PubMed - indexed for MEDLINE]

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Additional polymorphisms at marker loci D9S5 and D9S15 generate extended haplotypes in linkage disequilibrium with Friedreich ataxia. [Proc Natl Acad Sci U S A. 1990]
Additional polymorphisms at marker loci D9S5 and D9S15 generate extended haplotypes in linkage disequilibrium with Friedreich ataxia.
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Cited by 8 PubMed Central articles

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Blair IP, Nash J, Gordon MJ, Nicholson GA. Am J Hum Genet. 1996 Mar; 58(3):472-6.
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Genetic recombination events which position the Friedreich ataxia locus proximal to the D9S15/D9S5 linkage group on chromosome 9q.
Chamberlain S, Farrall M, Shaw J, Wilkes D, Carvajal J, Hillerman R, Doudney K, Harding AE, Williamson R, Sirugo G. Am J Hum Genet. 1993 Jan; 52(1):99-109.
An index marker map of chromosome 9 provides strong evidence for positive interference. [Am J Hum Genet. 1993]
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