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Cell. 2013 Apr 11;153(2):287-92. doi: 10.1016/j.cell.2013.03.013.

Higher-order assemblies in a new paradigm of signal transduction.

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  • 1Program in Cellular and Molecular Medicine, Children's Hospital Boston and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.


Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and temporal and spatial control of signal transduction.

Copyright ┬ę 2013 Elsevier Inc. All rights reserved.

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