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Mol Cell. 2013 Apr 11;50(1):1-2. doi: 10.1016/j.molcel.2013.03.024.

How do cells sense foreign DNA? A new outlook on the function of STING.

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  • 1Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel. d.wallach@weizmann.ac.il

Abstract

STING, a protein mediating signaling activation by cytosolic DNA and known to act downstream of DNA sensor proteins, is shown also to bind DNA directly, raising the need to clarify the relative contributions of these distinct binding modes to DNA sensing.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23582257
[PubMed]
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