Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis

Tuberk Toraks. 2013;61(1):50-3. doi: 10.5578/tt.1897.

Abstract

Despite the widespread use, suicidal ingestion of isoniazid is a rare condition in Turkey. We reported a case of acute isoniazid intoxication associated with alcohol intake presenting with convulsion, coma and metabolic acidosis. The patient was treated successfully with intravenous pyridoxine administration. Early recognation and appropriate treatment in the intensive care unit is very important to prevent mortality in patients with acute isoniazid toxicity.

Publication types

  • Case Reports

MeSH terms

  • Acidosis / chemically induced*
  • Acidosis / diagnosis
  • Acidosis / drug therapy
  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / adverse effects*
  • Coma / chemically induced*
  • Coma / diagnosis
  • Coma / drug therapy
  • Humans
  • Infusions, Intravenous
  • Isoniazid / administration & dosage
  • Isoniazid / adverse effects*
  • Male
  • Pyridoxine / administration & dosage
  • Pyridoxine / therapeutic use
  • Seizures / chemically induced*
  • Seizures / diagnosis
  • Seizures / drug therapy
  • Suicide, Attempted
  • Treatment Outcome
  • Turkey
  • Young Adult

Substances

  • Antitubercular Agents
  • Pyridoxine
  • Isoniazid