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Middle East Afr J Ophthalmol. 2013 Jan-Mar;20(1):11-25. doi: 10.4103/0974-9233.106382.

Strategies for local gene therapy of corneal allograft rejection.

Author information

  • 1The Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Abstract

Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and pharmacologic tools is available to improve graft survival. In this review, we will discuss the various gene therapeutic strategies aimed at potentiating the anterior chamber-associated immune deviation to extend graft survival.

KEYWORDS:

Adenovirus; Corneal Transplant; Dendrimer; Gene Therapy; Immune Privilege; Neovascularization; Plasmid; Rejection

PMID:
23580848
[PubMed - indexed for MEDLINE]
PMCID:
PMC3617523
Free PMC Article
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