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Ann Otol Rhinol Laryngol. 2013 Mar;122(3):177-82.

Mitochondrial myopathy: a rare cause of early-onset vocal fold atrophy.

Author information

  • 1Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Abstract

OBJECTIVES:

We present the second published case of laryngeal involvement in mitochondrial myopathy.

METHODS:

A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review.

RESULTS:

A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure.

CONCLUSIONS:

Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy.

PMID:
23577570
[PubMed - indexed for MEDLINE]
PMCID:
PMC3951151
Free PMC Article

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