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Nephrourol Mon. 2013 Winter;5(1):702-5. doi: 10.5812/numonthly.5251. Epub 2012 Dec 15.

Cigarette smoking and nephrolitiasis in adult individuals.

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  • 1Department of Internal Medicine, Fatemieh Hospital, Semnan University of Medical Sciences, Semnan, IR Iran.

Abstract

BACKGROUND:

Nephrolithiasis is a widespread multifactorial disorder. Constitutional, environmental and genetic factors play a role in stone formation. Although important advances have been made in understanding the pathophysiology of stone formation, none of the many theories have given a satisfactory explanation of this process.

OBJECTIVES:

The objective of study was to evaluate the probable relationship between cigarette smoking and nephrolitiasis in adult men.

PATIENTS AND METHODS:

A total of 102 cases diagnosed with nepholithiasis and 121 age-matched healthy controls were recruited from June 2010 to September 2011. Smoking status and resultant data was obtained from both groups.

RESULTS:

Twenty seven (26.5%) of the patients with stones and eighteen (14.9%) of the control group were current cigarette smokers. Our findings showed that smoking significantly increases the risk of nepholithiasis (OR = 2.06, 95% CI: 1.06-4.01, P = 0.034). There was no significant difference in the number of cigarettes smoked (P = 0.830) and years of smoking (P = 0.536) between subjects with and without stones (P = 0.536).

CONCLUSIONS:

This study suggests that cigarette smoking might be an independent risk factor for the development of nephrolithiasis.

KEYWORDS:

Adult; Nephrolithiasis; Risk factors; Smoking

PMID:
23577335
[PubMed]
PMCID:
PMC3614330
Free PMC Article
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