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J Am Chem Soc. 2013 Apr 24;135(16):5934-7. doi: 10.1021/ja312210c. Epub 2013 Apr 12.

Investigation of SSEA-4 binding protein in breast cancer cells.

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  • 1Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.


SSEA-4, a sialyl-glycolipid, has been commonly used as a pluripotent human embryonic stem cell marker, and its expression is correlated with the metastasis of some malignant tumors. However, there is no in-depth functional study related to the receptor and the role of this glycolipid. Here, we report the identification of an SSEA-4-binding protein in a breast cancer cell line, MCF-7. By using affinity capture and glycan microarray techniques, the intracellular FK-506 binding protein 4 (FKBP4) was identified to bind directly to SSEA-4. The biological significance of SSEA-4/FKBP4 interaction was investigated.

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