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Arch Neurol. 1990 Jul;47(7):810-2.

Autosomal dominant cramping disease.

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  • 1Department of Neurology, University of W├╝rzburg, West Germany.


A family was studied in which four generations (16 of 41 members) suffered from painful recurrent muscle cramping. A clear pattern of autosomal dominant inheritance was noted. The cramping first developed during adolescence or early adulthood. Electromyographic analysis indicated a neurogenic origin. The cramps seemed to be due to dysfunction of the motor neurons. The mechanisms underlying this alteration are unclear and require further investigation.

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