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Curr Opin Chem Biol. 2013 Jun;17(3):406-11. doi: 10.1016/j.cbpa.2013.03.022. Epub 2013 Apr 6.

Analytical and bioanalytical technologies for characterizing antibody-drug conjugates.

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  • 1Seattle Genetics, Inc., 21823 30th Drive SE, Bothell, WA 98021, United States. SAlley@seagen.com

Abstract

Antibody-drug conjugates (ADCs) require multiple assays for analytical and bioanalytical characterization due to their heterogeneous and dynamic nature. These assays can help address questions from the drug-loading distribution following conjugation to exposure-response relationships after dosing in vivo. This review describes new assay technologies that have been developed for physiochemical characterization and determination of pharmacokinetic parameters of ADCs.

Copyright © 2013 Elsevier Ltd. All rights reserved.

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