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Asian Pac J Trop Biomed. 2012 Nov;2(11):910-5. doi: 10.1016/S2221-1691(12)60252-4.

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats.

Author information

  • 1Animal tissue culture and Molecular genetics Laboratory, Department of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore-641 046, Tamilnadu, India.

Abstract

OBJECTIVE:

To assess the effect of quercetin (flavonoid) against lindane induced alterations in lipid profile of wistar rats.

METHODS:

Rats were administered orally with lindane (100 mg/kg body weight) and quercetin (10 mg/kg body weight) for 30 days. After the end of treatment period lipid profile was estimated in serum and tissue.

RESULTS:

Elevated levels of serum cholesterol, triglycerides, low density lipoprotein (LDL), very Low Density Lipoprotein (VLDL) and tissue triglycerides, cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.

CONCLUSIONS:

Our study suggests that quercetin has hypolipidemic effect and offers protection against lindane induced toxicity in liver by restoring the altered levels of lipids. The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane.

KEYWORDS:

High density lipoprotein; Lindane; Low density lipoprotein; Oxidative stress; Quercetin; Triglycerides; Very low density lipoprotein

PMID:
23569870
[PubMed - indexed for MEDLINE]
PMCID:
PMC3609243
Free PMC Article
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