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J Pediatr Neurosci. 2012 Sep;7(3):202-4. doi: 10.4103/1817-1745.106480.

Precocious puberty due to human chorionic gonadotropin secreting germinoma.

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  • 1Medical Student, University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.


This study aims to report a rare case of precocious puberty (PP) due to a human chorionic gonadotropin (hCG)-producing germinoma located in the suprasellar region. A 10-year-old male patient presented with sexual precocity, headache, drowsiness, loss of appetite, and papilledema. Significant acceleration of bone age in relation to chronological age, high serum total testosterone levels, and hypopituitarism (unresponsiveness to stimulation test) were observed. Magnetic resonance imaging (MRI) of the brain showed a large suprasellar tumor and triventricular dilatation. High hCG levels were found in both blood and cerebrospinal fluid. Hormone replacement therapy and transcranial surgery associated with radiotherapy were performed, with complete regression of sexual characteristics and normal laboratory tests post-operatively. Clinical and laboratory findings, in addition to MRI scans, led to the diagnosis of an hCG-producing tumor and PP, which represents a rare report in the literature.


Central nervous system neoplasms; chorionic gonadotropin; germinoma; precocious puberty

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