Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Antivir Ther. 2013;18(7):853-65. doi: 10.3851/IMP2565. Epub 2013 Apr 4.

The role of natural killer cells in hepatitis C infection.

Author information

  • 1Liver Transplant Unit, Austin Hospital, Melbourne, Australia. manukascarlet@yahoo.com.

Abstract

HCV infection is an exponentially growing health burden worldwide, with an estimated 170 million people infected. Although therapies for HCV are continually improving, there remain a considerable proportion of patients who do not achieve viral eradication and develop liver disease. Natural killer (NK) cells are crucial for T-cell activation and are one of the first-line sentinel cell responders to viral infection. A recent explosion in studies exploring the role of NK cells in HCV infection has yielded important mechanistic information and intriguing potential therapeutic options for HCV infection. This review provides a general overview of normal NK cell function and outlines some of the important mechanisms characterizing the immune interplay between NK cells and HCV infection.

PMID:
23559549
[PubMed - in process]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk