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Ther Deliv. 2013 Apr;4(4):463-70. doi: 10.4155/tde.13.11.

Continuous processing and the applications of online tools in pharmaceutical product manufacture: developments and examples.

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  • 1Department of Pharmacy, National University of Singapore, Singapore.


Continuous processing and production in pharmaceutical manufacturing has received increased attention in recent years mainly due to the industries' pressing needs for more efficient, cost-effective processes and production, as well as regulatory facilitation. To achieve optimum product quality, the traditional trial-and-error method for the optimization of different process and formulation parameters is expensive and time consuming. Real-time evaluation and the control of product quality using an online process analyzer in continuous processing can provide high-quality production with very high-throughput at low unit cost. This review focuses on continuous processing and the application of different real-time monitoring tools used in the pharmaceutical industry for continuous processing from powder to tablets.

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