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Org Lett. 2013 May 3;15(9):2168-71. doi: 10.1021/ol400694h. Epub 2013 Apr 3.

Isolation and photoinduced conversion of 6-epi-stephacidins from Aspergillus taichungensis.

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  • 1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, 266003, PR China.

Erratum in

  • Org Lett. 2013 Aug 2;15(15):4042.


Three prenylated indole alkaloids with a rare anti bicyclo-[2.2.2]diazaoctane core ring (5-7) were isolated from Aspergillus taichungensis. The structures including absolute configurations were elucidated based on NMR, X-ray, and CD methods. (+)-Versicolamides B and C (8-9) which contain a spiro-center, together with seven analogues (7, 10-15), were isolated as photoinduced conversion products of 6. Biological evaluation indicated that 6 and 7 exhibited significant cytotoxicities with IC50 values in the low micromolar range.

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