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Iran J Pediatr. 2013 Feb;23(1):105-8.

Generalized lymphadenopathy in infancy; a case report.

Author information

  • 1Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Rosai-Dorfman disease (RDD) is a rare disease of histiocytic cells, a cause of benign cervical lymphadenopathy (LAP) and massive generalized lymph node enlargement in children and adults. There are also some reports on involvement of other human body organs with or without LAP.

CASE PRESENTATION:

A 7-month-old infant with chief complaint of generalized massive LAP was referred to our center. RDD was diagnosed according to clinical manifestations and confirmed through histopathologic and immunoreactivity study on the obtained sample by cervical lymph node biopsy.

CONCLUSION:

RDD is not a malignant illness and lymph node enlargement most often decreases in its size happens without special treatment.

KEYWORDS:

Generalized Lymphadenopathy; Histiocytosis; Infant; Rosai-Dorfman Disease

PMID:
23548976
[PubMed]
PMCID:
PMC3575001
Free PMC Article
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