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Ann Allergy Asthma Immunol. 2013 Mar;110(3):173-177.e1. doi: 10.1016/j.anai.2012.12.006. Epub 2013 Jan 8.

Relating microarray component testing and reported food allergy and food-triggered atopic dermatitis: a real-world analysis.

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  • 1Division of Allergy and Immunology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.



High epitope diversity has been associated with increased IgE-mediated food allergy severity.


To characterize associations between results from an automated microarray system and self-reported food allergy and food-triggered atopic dermatitis (AD).


Families with food allergic children were identified from a Jewish community in Lakewood, New Jersey, with immediate family members without food allergy or food-triggered AD serving as controls for the identified children. Sets of microarray components analyzed were to milk (Bos d 4, Bos d 5, Bos d 8, Bos d lactoferrin), egg (Gal d 1, Gal d 2, Gal d 3, Gal d 5), and peanut (Ara h 1, Ara h 2, Ara h 3, Ara h 6).


Seventy-three patients from 23 families were recruited. Culprit foods included milk (n = 20), egg (n = 10), and peanut (n = 6) for food allergy and milk (n = 10) and egg (n = 7) for food-triggered AD. Odds of having had a self-reported related food allergy or food-triggered AD reaction significantly increased with a higher number of detectable microarray components to that food. Ara h 1, Ara h 2, and Ara h 6 were individually associated with reported peanut allergy, and Bos d 4 was individually associated with reported milk allergy. The number of egg components significantly increased the odds of having related food-triggered AD.


High diversity of food allergen components relates well to self-reported history of food allergy and food-associated AD.

Copyright © 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

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