Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris

J Drugs Dermatol. 2013 Mar;12(3):266-9.

Abstract

This study evaluated the tolerance and efficacy of 2 facial skin products in subjects with acne using the following acne treatments: 1) treatment A, a combination of salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid, and 2) treatment B (BenzaClin®, clindamycin 1% and benzoyl peroxide 5% gel). The treatment design included the split-face application of treatment A and treatment B and the full-face application of the cleanser, moisturizer, and sunscreen. Data were collected through physician visual assessments, subject irritation questionnaires and assessments, along with clinical photography. Results showed similar tolerance and efficacy for both treatments.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / pathology
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Benzoyl Peroxide / administration & dosage
  • Benzoyl Peroxide / adverse effects
  • Benzoyl Peroxide / therapeutic use*
  • Clindamycin / administration & dosage
  • Clindamycin / adverse effects
  • Clindamycin / therapeutic use*
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / adverse effects
  • Dermatologic Agents / therapeutic use*
  • Drug Combinations
  • Female
  • Gels
  • Humans
  • Male
  • Single-Blind Method
  • Skin Care / methods
  • Sunscreening Agents / administration & dosage
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult

Substances

  • Dermatologic Agents
  • Drug Combinations
  • Gels
  • Sunscreening Agents
  • clindamycin phosphate benzoyl peroxide combination
  • Clindamycin
  • Benzoyl Peroxide