Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Carbohydr Polym. 2013 Apr 15;94(1):56-62. doi: 10.1016/j.carbpol.2013.01.006. Epub 2013 Jan 11.

Hypolipidemic and antioxidant activities of polysaccharides from Rosae Laevigatae Fructus in rats.

Author information

  • 1Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.

Abstract

Two major fractions (RLP-1 and RLP-2) were obtained by purifying the crude polysaccharides extracted from a traditional Chinese herb Rosae Laevigatae Fructus. The average molecular weight of RLP-1 and RLP-2 was 21.5 kDa and 16.1 kDa, respectively. Monosaccharide analysis indicated that RLP-1 was composed of xylose, mannose and galactose in the molar ratio of 1:11:8, while RLP-2 was only a glucan. Oral administration of RLP-1 could significantly decrease levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), inhibit hepatic lipid accumulation, increase antioxidant lipids and up-regulate expressions of peroxisome proliferator-activated receptor-γ (PPAR-γ) and lipoprotein lipase (LPL) in hyperlipidemia rats. These results suggest that RLP-1 improve hyperlipidemia possibly through regulating PPAR-mediated lipid metabolism. Therefore, could be explored as a possible agent for hyperlipidemia.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23544509
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk