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Carbohydr Polym. 2013 Apr 15;94(1):56-62. doi: 10.1016/j.carbpol.2013.01.006. Epub 2013 Jan 11.

Hypolipidemic and antioxidant activities of polysaccharides from Rosae Laevigatae Fructus in rats.

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  • 1Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.


Two major fractions (RLP-1 and RLP-2) were obtained by purifying the crude polysaccharides extracted from a traditional Chinese herb Rosae Laevigatae Fructus. The average molecular weight of RLP-1 and RLP-2 was 21.5 kDa and 16.1 kDa, respectively. Monosaccharide analysis indicated that RLP-1 was composed of xylose, mannose and galactose in the molar ratio of 1:11:8, while RLP-2 was only a glucan. Oral administration of RLP-1 could significantly decrease levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), inhibit hepatic lipid accumulation, increase antioxidant lipids and up-regulate expressions of peroxisome proliferator-activated receptor-γ (PPAR-γ) and lipoprotein lipase (LPL) in hyperlipidemia rats. These results suggest that RLP-1 improve hyperlipidemia possibly through regulating PPAR-mediated lipid metabolism. Therefore, could be explored as a possible agent for hyperlipidemia.

Copyright © 2013 Elsevier Ltd. All rights reserved.

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