Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Cardiol. 2013 Oct 3;168(3):2506-9. doi: 10.1016/j.ijcard.2013.03.011. Epub 2013 Mar 29.

Carotid body removal for treatment of chronic systolic heart failure.

Author information

  • 1Department of Cardiology, Centre for Heart Disease, 4th Military Hospital, Wroclaw, Poland. Electronic address: pnsky@wp.pl.

Abstract

BACKGROUND:

Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome.

METHODS AND RESULTS:

We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.

CONCLUSIONS:

Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821).

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Autonomic imbalance; Carotid body chemoreceptors; Heart failure; Surgical resection

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk