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J Affect Disord. 2013 Sep 5;150(2):649-52. doi: 10.1016/j.jad.2013.02.036. Epub 2013 Mar 26.

Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients.

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  • 1Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Abstract

BACKGROUND:

Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders.

METHODS:

We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156).

RESULTS:

Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding.

LIMITATIONS:

These findings did not survive correction for multiple testing and should be interpreted with caution.

CONCLUSION:

Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.

Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

Depression; Serotonin genes; Social adjustment

PMID:
23537781
[PubMed - indexed for MEDLINE]
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