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J Affect Disord. 2013 Sep 5;150(2):649-52. doi: 10.1016/j.jad.2013.02.036. Epub 2013 Mar 26.

Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients.

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  • 1Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.



Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders.


We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156).


Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding.


These findings did not survive correction for multiple testing and should be interpreted with caution.


Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.

Copyright © 2013 Elsevier B.V. All rights reserved.


Depression; Serotonin genes; Social adjustment

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