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Dev Cell. 2013 Mar 25;24(6):563-4. doi: 10.1016/j.devcel.2013.02.018.

Bidirectional myoblast-pericyte plasticity.

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  • 1Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.


Microvascular pericytes are able to generate multiple mesenchymal cell types, including skeletal muscle myoblasts. Cappellari et al. (2013) report in this issue of Developmental Cell that myoblasts can return the favor by generating pericytes via the action of Dll4 Notch ligand and PDGF-BB.

Copyright © 2013 Elsevier Inc. All rights reserved.

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