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Chem Soc Rev. 2013 Jun 21;42(12):5102-18. doi: 10.1039/c3cs35525j.

Recent developments in design and synthesis of bicyclic azasugars, carbasugars and related molecules as glycosidase inhibitors.

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  • 1Department of Chemistry, Indian Institute of Technology, Kanpur-208016, India.

Abstract

The importance of glycosidase inhibitors and especially the bicyclic molecules has led to design and assessment of many analogs of naturally occurring molecules. This review focuses on the synthesis and enzyme inhibitions of a few selected (synthetic or non-naturally occurring) molecules that have been reported in the last decade, which allow one to draw some connection between varying the structural features and their effect on glycosidase inhibitions. It is expected that further improvements based on these features could lead to improved inhibitors.

PMID:
23535828
[PubMed - indexed for MEDLINE]
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