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Endocr J. 2013;60(7):861-70. Epub 2013 Mar 27.

Association of CYP11B2 polymorphisms with susceptibility to primary aldosteronism: a meta-analysis.

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  • 1Department of Endocrinology and Metabolism, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Abstract

The association of CYP11B2 gene polymorphisms with the risk of primary aldosteronism (PA) was controversial in previous studies. Here we selected two commonly studied CYP11B2 alleles: T-344C, A2718G to explore their associations with PA risk by meta-analyses of published case-control studies. Six electronic databases were searched for relevant studies up to November 2012. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random or fixed effects model. Seven studies (621 cases and 1027 controls) on T-344C polymorphism, three studies (327 cases and 336 controls) on A2718G polymorphism were finally included. Then significant association was observed between T-344C polymorphism and idiopathic hyperaldosteronism (IHA) under three genetic models (CC vs. TT, OR=0.544, 95% CI=0.324~0.914; CT vs. TT, OR=0.554, 95% CI=0.406~0.757; CC+CT vs. TT, OR=0.542, 95% CI=0.402~0.731). But patients with aldosterone-producing adenoma had no significant association with T-344C polymorphism under all genetic models except CT vs. TT model. Concerning A2718G polymorphism, a decreased PA risk was observed only under GG+GA vs AA model. But this association disappeared after removing the studies not in Hardy-Weinberg equilibrium. The evidence accumulated suggested that -344C allele may be associated with decreased risk of IHA and there was still no enough evidence to indicate the association of A2718G polymorphism with PA risk.

PMID:
23535359
[PubMed - indexed for MEDLINE]
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