Send to:

Choose Destination
See comment in PubMed Commons below
Phytochemistry. 2013 Jun;90:56-61. doi: 10.1016/j.phytochem.2013.02.007. Epub 2013 Mar 25.

Biotransformation of clerodane diterpenoids by Rhizopus stolonifer and antibacterial activity of resulting metabolites.

Author information

  • 1H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.


Microbial transformation of clerodane lactone (1) by a plant pathogen fungus, Rhizopus stolonifer, resulted in the production of metabolites 3 and 4. While incubation of clerodane methyl ester (2) by R. stolonifer yielded metabolites 5-8. The structures of the transformed products were determined by the spectroscopic techniques and compounds 4, 7 and 8 were found. The antibacterial activity of clerodane diterpenoids 1 and 2 and their metabolites 3-8 were also studied. The metabolites 3-7 showed moderate activities against both Gram-positive and Gram-negative organisms. While metabolite 8 showed a moderate activity against Gram-positive organisms and a good activity against Gram-negative organisms.

Copyright © 2013 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk