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Asian Pac J Cancer Prev. 2013;14(1):275-9.

Chronic hepatitis B virus infection and risk of pancreatic cancer: a meta-analysis.

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  • 1Department of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan, China.

Abstract

OBJECTIVES:

A number of studies have shown that chronic hepatitis B virus infection is implicated in susceptibility to pancreatic cancer. However, the results are still controversial. This meta-analysis aimed to quantitatively assess the relationship between chronic hepatitis B virus infection and incidence of pancreatic cancer of cohort and case-control studies.

METHODS:

A literature search was performed for entries from 1990 to 2012 using PUBMED and EMBASE. Studies were included if they reported odds ratios (ORs) and corresponding 95% CIs of pancreatic cancer with respect to the infection of hepatitis B virus.

RESULTS:

Eight studies met the inclusion criteria, which included five case-control studies and three cohort studies. Compared with individuals who have not infection of hepatitis B virus, the pooled OR of pancreatic cancer was 1.403 (95%CI: 1.139-1.729, P=0.001) for patients with hepatitis B virus infection. Sub-group analysis by study design showed that the summary OR was 1.43 (95%CI: 1.06-1.94, P=0.021) when pooling case-control studies and 1.31 (95%CI: 1.00- 1.72, P=0.05) when pooling cohort studies.

CONCLUSION:

Findings from this meta-analysis suggest that chronic hepatitis B virus infection may increase the risk of pancreatic cancer. This relationship needs to be confirmed by further follow-up studies.

PMID:
23534737
[PubMed - indexed for MEDLINE]
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