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Bioanalysis. 2013 Apr;5(7):769-81. doi: 10.4155/bio.13.40.

The metabolism of anabolic-androgenic steroids in the greyhound.

Author information

  • 1Australian Racing Forensic Laboratory. Currently with the Department of the President's Affairs, PO Box 17292, Al Ain, United Arab Emirates. amckinney@mscpc.ae

Abstract

BACKGROUND:

Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region.

RESULTS:

Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5β- or 3β,5α-stereochemistry, the oxidation of secondary 17β-hydroxyl groups and 16α-hydroxylation. The Phase II β-glucuronylation of sterol metabolites was extensive.

CONCLUSION:

The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples.

PMID:
23534422
[PubMed - indexed for MEDLINE]
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