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Chem Commun (Camb). 2013 May 7;49(35):3643-5. doi: 10.1039/c3cc41619d. Epub 2013 Mar 25.

A sensitive SERS assay of L-histidine via a DNAzyme-activated target recycling cascade amplification strategy.

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  • 1Key Laboratory of Biochemical Analysis, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.


A novel surface-enhanced Raman scattering (SERS) method is demonstrated to detect L-histidine based on DNAzyme which can specifically recognize L-histidine. Through a target recycling cascade amplification strategy, the DNAzyme-based SERS sensing system affords very high sensitivity for L-histidine with a detection limit of 0.56 nM.

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