Format

Send to

Choose Destination
See comment in PubMed Commons below
Autophagy. 2013 Jun 1;9(6):936-8. doi: 10.4161/auto.24397. Epub 2013 Mar 25.

Spread of neuronal degeneration in a dopaminergic, Lrrk-G2019S model of Parkinson disease.

Author information

  • 1Department of Biology, University of York, York, UK.

Abstract

Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopaminergic, this demonstrates nonautonomous degeneration, and a spread of pathology. This provides a model consistent with Braak's hypothesis on progressive PD. The loss of visual function is specific for the G2019S mutation, implying the cause is its increased kinase activity, and is enhanced by increased neuronal activity. These data suggest novel explanations for the variability in animal models of PD. The specificity of visual loss to G2019S, coupled with the differences in neural firing rate, provide an explanation for the variability between people with PD in visual tests.

KEYWORDS:

Drosophila; LRRK2; Parkinson disease; dopaminergic neurons; electroretinogram; neurodegeneration; photoreceptors; vision

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Write to the Help Desk