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Clin Transplant. 2013 May-Jun;27(3):E302-7. doi: 10.1111/ctr.12115. Epub 2013 Mar 26.

Intermediate-term outcome of single kidney grafts from pediatric donors weighing 10-14 kg in adult recipients.

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  • 1Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.

Abstract

BACKGROUND:

Kidneys from pediatric donors weighing <10 kg are preferably transplanted en bloc, while kidneys from donors weighing >15 kg can be safely transplanted as single kidneys. However, single kidney transplantation from donors weighing 10-14 kg is controversial and has not been well investigated.

METHODS:

We analyzed the outcome of 15 recipients of single kidneys from donors weighing 10-14 kg (study group) with 40 recipients receiving an allograft from ideal deceased donors (control group).

RESULTS:

After a follow-up of three yr, death-censored graft survival was 100% in both groups. The calculated creatinine clearance was lower in the study group at six months (53 vs. 71 mL/min; p = 0.01) and similar at 12 months (68 vs. 68 mL/min; p = 0.48), 24 months (81 vs. 70 mL/min; p = 0.58), and 36 months (74 vs. 69 mL/min; p = 0.59). Urinary albumin/creatinine ratios were comparable between the two groups up to two yr. At three yr, urinary albumin/creatinine ratios were higher in the study group than the control group (10.5 vs. 0.9 mg/mmol; p = 0.007). Surveillance biopsies at three and six months post-transplant revealed no evidence for focal segmental glomerulosclerosis in the study group.

CONCLUSIONS:

Transplantation of single pediatric kidneys from donors weighing 10-14 kg into adult recipients provides excellent intermediate-term outcomes. Low-grade albuminuria, three yr post-transplant, might indicate late-onset hyperfiltration injury.

© 2013 John Wiley & Sons A/S.

PMID:
23528134
[PubMed - indexed for MEDLINE]
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