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Case Rep Oncol. 2012 May;5(2):400-3. doi: 10.1159/000341663. Epub 2012 Jul 24.

Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion.

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  • 1Department of Dermatology, Meiwa Hospital, Nishinomiya, Osaka, Japan.

Abstract

We performed immunohistochemical studies of epithelial keratins in intraductal carcinoma in situ (IDCIS) in mammary Paget's disease (MPD). K7, K8 and K18 were expressed in IDCIS in MPD. However, K19 was not expressed in IDCIS in MPD. Interestingly, K17 was expressed in some tumor cells in IDCIS. K17, a hyperproliferative keratin, may suggest ductal invasion and poor prognosis in MPD.

KEYWORDS:

Intraductal carcinoma; Keratins; Mammary Paget's disease

PMID:
23525171
[PubMed]
PMCID:
PMC3409513
Free PMC Article
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