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Medchemcomm. 2013 Feb 1;4(2):406-410. Epub 2012 Nov 29.

A structure-activity relationship study on multi-heterocyclic molecules: two linked thiazoles are required for cytotoxic activity.

Author information

  • 1School of Chemistry, 219 Dalton, Gate 2 High Street, University of New South Wales, Sydney, NSW, 2052, Australia. Tel: +61-4-1672-8896.

Abstract

We report the synthesis, cytotoxicity, and phenotypic analysis of oxazole and thiazole containing fragments. Evaluating the optimal size and heterocycle for growth inhibition and apoptosis showed that activity required at least two thiazoles sequentially connected. This is the first detailed comparison of biological activity between multi-heterocyclic containing fragments.

PMID:
23524379
[PubMed]
PMCID:
PMC3601786
Free PMC Article

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