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J Child Neurol. 2014 Jun;29(6):769-73. doi: 10.1177/0883073813480392. Epub 2013 Mar 20.

Limbic encephalitis associated with elevated antithyroid antibodies.

Author information

  • 1Children's Neurosciences Center, Evelina Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, King's Health Partners Academic Health Sciences Centre, London, UK Nuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • 2Department of Paediatrics, Royal Hospital for Sick Children, Edinburgh, UK.
  • 3Department of Neurology, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, UK.
  • 4Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh, UK.
  • 5Children's Neurosciences Center, Evelina Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, King's Health Partners Academic Health Sciences Centre, London, UK.
  • 6Nuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • 7Children's Neurosciences Center, Evelina Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, King's Health Partners Academic Health Sciences Centre, London, UK Nuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK ming.lim@gstt.nhs.uk.

Abstract

Immune-mediated limbic encephalitis affects both adults and children. Patients typically present with seizures, memory problems, and imaging changes in the medial temporal lobes. Both paraneoplastic and nonparaneoplastic forms have been described in which the antibody to the voltage-gated potassium channel-complex associated protein, leucine-rich glioma-inactivated 1, is most commonly reported. Elevated antithyroid antibodies have also been reported in a range of neurological syndromes with encephalopathy, such as limbic encephalitis, often collectively termed Hashimoto encephalopathy, a condition whereby corticosteroids responsiveness with a complete recovery is commonly observed. Here we describe 3 children presenting with limbic encephalitis with elevated thyroid antibodies that did not respond to corticosteroids alone and required more aggressive immunotherapy, mirroring the slower treatment response that is more frequently seen in other immune-mediated forms of limbic encephalitis.

© The Author(s) 2013.

KEYWORDS:

Hashimoto; autoantibodies; encephalitis; encephalopathy; epilepsy; limbic system

PMID:
23520363
[PubMed - in process]
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