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Mov Disord. 2013 Jul;28(8):1146-9. doi: 10.1002/mds.25438. Epub 2013 Mar 20.

Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease.

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  • 1Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. lamachahine@hotmail.com



Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach.


The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo questionnaire were prospectively validated.


Seventy-five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%-100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n=65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%-92.6%).


A combination of patient and bed-partner questionnaires is a useful tool to detect RBD.

Copyright © 2013 Movement Disorder Society.


Parkinson's disease; REM sleep behavior disorder

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