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Bioinformation. 2013;9(4):187-92. doi: 10.6026/97320630009187. Epub 2013 Feb 21.

Identification of potential targets in Staphylococcus aureus N315 using computer aided protein data analysis.

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  • 1Department of Genetic Engineering & Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong -4331, Bangladesh.

Abstract

Staphylococcus aureus is a gram positive bacterium, responsible for both community-acquired and hospital-acquired infection, resulting in a mortality rate of 39%. 43.2% resistance to methicilin and emerging resistance to Fluroquinolone and Oxazolidinone, have evoked the necessity of the establishment of alternative and effective therapeutic approach to treat this bacteria. In this computational study, various database and online software are used to determine some specific targets of Staphylococcus aureus N315 other than those used by Penicillin, Quinolone and Oxazolidinone. For this purpose, among 302 essential proteins, 101 nonhomologous proteins were accrued and 64 proteins which are unique in several metabolic pathways of S. aureus were isolated by using metabolic pathway analysis tools. Furthermore, 7 essentially unique enzymes involved in exclusive metabolic pathways were revealed by this research, which can be potential drug target. Along with these important enzymes, 15 non-homologous proteins located on membrane were identified, which can play a vital role as potential therapeutic targets for the future researchers.

KEYWORDS:

Essential proteins; Staphylococcus aureus; Surface; Therapeutic targets

PMID:
23519164
[PubMed]
PMCID:
PMC3602888
Free PMC Article
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