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Microbes Infect. 2013 Jun;15(6-7):506-10. doi: 10.1016/j.micinf.2013.03.003. Epub 2013 Mar 19.

Chemically modified bovine beta-lactoglobulin inhibits human papillomavirus infection.

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  • 1Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China. lul@fudan.edu.cn

Abstract

Previous studies have shown that 3-hydroxyphthalic anhydride-modified bovine beta-lactoglobulin is a promising anti-HIV microbicide candidate. Here we found that this chemically modified protein, designated JB01, exhibited highly potent antiviral activity against infection by human papillomaviruses (HPV), including HPV6, HPV16 and HPV18. Its anti-HPV activity was correlated with the percentage of modified lysine and arginine residues in JB01. This modified milk protein had no cytotoxicity at the concentration of 1 mg/ml, and it is highly stable at room temperature and 37 °C for at least 12 weeks. These results suggest that JB01 has good potential to be developed as an effective, safe and inexpensive antiviral agent for treatment and prevention of HPV infection.

Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

PMID:
23518265
[PubMed - indexed for MEDLINE]
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