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Appl Microbiol Biotechnol. 2013 May;97(10):4235-41. doi: 10.1007/s00253-013-4841-x. Epub 2013 Mar 21.

Alternative splicing in ascomycetes.

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  • 1Abteilung für Botanische Genetik und Molekularbiologie, Botanisches Institut und Botanischer Garten, Christian-Albrechts-Universität zu Kiel, Olshausenstr. 40, 24098 Kiel, Germany. fkempken@bot.uni-kiel.de

Abstract

Alternative splicing is a complex and regulated process, which results in mRNA with different coding capacities from a single gene. Extend and types of alternative splicing vary greatly among eukaryotes. In this review, I focus on alternative splicing in ascomycetes, which in general have significant lower extend of alternative splicing than mammals. Yeast-like species have low numbers of introns and consequently alternative splicing is lower compared to filamentous fungi. Several examples from single studies as well as from genomic scale analysis are presented, including a survey of alternative splicing in Neurospora crassa. Another focus is regulation by riboswitch RNA and alternative splicing in a heterologous system, along with putative protein factors involved in regulation.

PMID:
23515838
[PubMed - indexed for MEDLINE]
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