Format

Send to

Choose Destination
See comment in PubMed Commons below
Fam Pract. 2013 Aug;30(4):404-10. doi: 10.1093/fampra/cmt010. Epub 2013 Mar 20.

Tolerance to benzodiazepines among long-term users in primary care.

Author information

  • 1Department of Primary and Community Care, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

Abstract

BACKGROUND:

Tolerance towards the effects of benzodiazepines is observed in various animal and human studies. Therefore, it is assumed that patients who use benzodiazepines for a longer period of time need to increase their dose over time to experience the same effect.

OBJECTIVE:

To observe whether long-term benzodiazepine users increase their dose over time.

METHODS:

From the Dutch National Information Network of Family Practices, a group of long-term benzodiazepine users was identified. This group was divided into an incident long-term benzodiazepine users group (N = 113) and a prevalent long-term benzodiazepine users group (N = 992). Long-term use of benzodiazepines was defined as usage for at least 6 months. The main outcome was a change in prescribed dose from baseline until 24 months after baseline. Linear regression analysis was performed to evaluate dose change.

RESULTS:

Neither incident long-term benzodiazepine users nor prevalent long-term benzodiazepine users were prescribed increasing dosages during follow-up.

CONCLUSION:

There is no increase in prescribed dose among long-term users, as might be expected due to the development of tolerance to the effects of benzodiazepines.

KEYWORDS:

Anxiety/anxiety; abuse (not tobacco).; clinical; disorder; longitudinal; primary care; psychiatry; research; sleep disorders; substance

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk