Send to

Choose Destination
See comment in PubMed Commons below
J Chromatogr Sci. 2013 Aug;51(7):666-83. doi: 10.1093/chromsci/bmt012. Epub 2013 Mar 20.

Recent advances in enhancing the sensitivity and resolution of capillary electrophoresis.

Author information

  • 1College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.


An extensive search of published research and review articles indicates that enhancing the sensitivity and resolution of capillary electrophoresis (CE) is a very active area of interest. This review focuses on developments and applications in this field over several years, especially from 2009-present. It first reviews developments in the fields of online sample preconcentration and highly sensitive detection for sensitivity enhancement. The online sample preconcentration techniques cover all methods, from electrophoretic preconcentration, extraction-based preconcentration, micelle-based preconcentration and hybrid preconcentration to nanoparticle-based preconcentration. Attention is also given to multiple dimension separations, additives in buffer solution and capillary inner surface modifications that have been used to enhance the resolution and separation efficiency of complex samples in CE. The additives include nanoparticles, chiral selectors and other buffer additives that have been added to the buffer solution.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk