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Biochem Soc Trans. 2013 Apr;41(2):475-90. doi: 10.1042/BST20130014.

Mechanisms of microbial escape from phagocyte killing.

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  • 1Institute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.

Abstract

Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to avoid killing by phagocytic cells. The present review discusses a key innate immune cell, the macrophage, and highlights the myriad mechanisms microbes have established to escape phagocytic killing.

PMID:
23514140
[PubMed - indexed for MEDLINE]
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