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Curr Opin Struct Biol. 2013 Apr;23(2):235-42. doi: 10.1016/j.sbi.2013.02.009. Epub 2013 Mar 16.

Structural insights into Elongator function.

Author information

  • 1European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Abstract

The eukaryotic Elongator complex was initially identified in yeast as a RNA polymerase II (Pol II) associated transcription elongation factor, although there is accumulating evidence that its main cellular function is the specific modification of uridines at the wobble base position of tRNAs. Elongator complex is built up by six highly conserved subunits and was shown to be involved in a variety of different cellular activities. Here, we summarize structural and functional information on individual Elongator subunits or subcomplexes. On the basis of homology models of the Elp1, Elp2 and Elp3 subunits and the crystal structure of the Elp456 subcomplex, the role of each subunit in Elongator complex assembly and catalytic activity is discussed.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23510783
[PubMed - indexed for MEDLINE]
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