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Cell Prolif. 2013 Apr;46(2):232-42. doi: 10.1111/cpr.12024.

Identification and biological characterization of chicken embryonic cardiac progenitor cells.

Author information

  • 1Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Abstract

OBJECTIVES:

Many kinds of cardiac progenitor cell populations have been identified, including c-kit(+) , Nkx2.5(+) s and GATA4(+) cells. However, these progenitors have limited ability to differentiate into different cardiac cell types. Recently, a new kind of cardiac progenitor cell named the multipotent Isl1(+) cardiovascular progenitor (MICPs) has been identified, which also expresses Nkx2.5, GATA4, CD34 and Flk1.

MATERIALS AND METHODS:

In this study, we have isolated and characterized MICPs from chicken embryonic heart tissues using immunofluorescence and PCR.

RESULTS:

Results shown that they express markers of cardiac progenitor cells, with high clonality. They have the ability to self-renew and can give rise to three types of heart cell in vitro.

CONCLUSIONS:

Myocytes, smooth muscle cells and endothelial cells. Our work provides evidence for a developmental paradigm of the heart, that endothelial and muscle lineage diversification arises from multipotent cardiac progenitor cells. Existence of these cells provides a new opportunity for myocardial injury repair.

© 2013 Blackwell Publishing Ltd.

PMID:
23510478
[PubMed - indexed for MEDLINE]
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